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VAC_13_2025 - LAB ASSISTANT TECHNICIAN (Cancer Metabolism...

Institut de Recerca contra la Leucèmia Josep Carreras
4.5 de 5 estrellas
08916 Badalona, Barcelona provincia
Trabajo híbrido
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Ubicación

08916 Badalona, Barcelona provinciaTrabajo híbrido

Descripción completa del empleo

The Josep Carreras Leukaemia Research Institute (IJC) is a comprehensive cancer research center dedicated to conduct research and drive innovation in the epidemiological, preventive, clinical, translational, and basic aspects of leukaemia and other hematologic malignancies, with the final aim of finding a cure for these diseases. It was created in 2010, and since then has experienced an exponential growth.

The IJC is also part of the network of Excellence Research Centers of Catalonia (CERCA) and was accredited as a Severo Ochoa Center of Excellence by the Ministry of Science, Innovation, and Universities in 2024. Since 2018, the Institute has also been accredited by the Scientific Foundation of the Spanish Association Against Cancer (FCAECC) Additionally, IJC is one of the centers integrated into the Institut de Recerca Germans Trias i Pujol (IGTP) accreditation as Accredited Health Research Institute (IIS) by the Carlos III Health Institute (ISCIII).

The IJC's main headquarters is located within the Can Ruti Biomedical Campus, alongside other leading biomedical institutions, providing direct access to cutting-edge scientific and technological facilities, as well as complementary community services. The IJC has six locations integrated into reference hospitals: Hospital Germans Trias i Pujol, Hospital Clínic, Hospital Sant Pau, Hospital Josep Trueta, Hospital del Mar and Hospital San Joan de Déu. This facilitates close collaboration between basic and clinical researchers, fostering translational research that integrates basic science with clinical practice in clinical settings.

The Josep Carreras Leukemia Research Institute Can Ruti is looking for a Lab Assistant Technician for the Cancer Metabolism group led by Dr. Lucas Pontel.


RESEARCH DESCRIPTION

Cancer is a major global health concern and understanding its underlying mechanisms is essential for developing effective treatments. Cancer cells undergo genetic and epigenetic changes, activating oncogenes and silencing tumor suppressor genes. These malignant cells also exhibit metabolic reprogramming for obtaining energy and nutrients differently than normal cells, granting them a growth advantage. To sustain this uncontrolled growth, cancer cells depend on robust antioxidant defenses, primarily provided by abundant nucleophilic molecules such as glutathione (GSH).

This project is focused on investigating and harnessing the functions of cellular nucleophilic metabolites, such as glutathione and cysteine, in the protection of the cancer genome and in the maintenance of the epigenome in cancer cells. Our endeavor involves the implementation of comprehensive genome-wide omics methodologies, including pooled CRISPR/screens within cellular models representative Acute Myeloid Leukemia (AML). Through this research, we aim to pioneer novel therapeutic strategies that trigger cell death in leukemic cells by precisely targeting metabolic pathways integral to defense mechanisms against detrimental metabolites.

For further information please contact lpontel@carrerasresearch.org

This contract is part of the project PID2022-136694NB-I00 funded by MCIN/AEI/10.13039/501100011033/ EDRF ‘A way to make Europe’, UE.

WHAT WE NEED

General skills

  • Committed scientist with a competitive scientific record and experience in biology, biomedicine or related discipline.
  • A high level of motivation and interest in biomedical research.
  • Good communication skills.

Technical skills

  • Degree in Biology or Biochemistry (or related field).
  • MSc in Biology or Biochemistry (or related field).
  • A high-level of motivation and interest
  • Experience in molecular biology and cellular biology.
  • High level of collaborative and communicative skills.
  • High level of English speaking and writing skills (required). Spanish (helpful).


MAIN RESPONSABILITIES

  • Establish and maintain cellular models relevant for the aim of the project.
  • Apply cell biology and molecular biology techniques to characterize the cellular models.
  • Contribute to carry out CRISPR/Cas9 genome-wide screenings.
  • Assist in lab organization tasks like inventory tracking, reagent preparation, and supply ordering.
  • Collect and record experimental data, ensuring meticulous record-keeping and data quality.
  • Engage in literature reviews to stay updated on relevant advancements.
  • Collaborate effectively with the research team, contributing to lab meetings and discussions.
  • Seize opportunities for skill development and scientific growth.


WHAT WE OFFER

  • 6 months trainee contract, with possibility of a 6-month extension.
  • Start date: March 2025.
  • A salary that with commensurate your qualifications.
  • The stimulating environment of the IJC and its scientific network.
  • Support for applications to eligible fellowships for pursue a PhD career.


DEADLINE

Please submit your application by 28th of February.


WHO WE ARE?

What makes us different?

The mission of the Josep Carreras Institute is to conduct research and drive innovation in the epidemiological, preventive, clinical, translational, and basic aspects of leukaemia and other hematologic malignancies, with the final aim of finding a cure for these diseases.
The IJC’s vision is to be a world-class reference and excellent research multicampus that contributes to the improvement of results, and the cure of patients affected by leukemia and other malignant hemopathies, through innovation, sustainability, social responsibility, talent, and professional experience.

HR Excellence

In 2019, IJC was honored with the “Human Resources Excellence in Research Award” by the European Commission, recognizing the alignment of our human resources policies with the European Charter for Researchers and Code of Conduct for the Recruitment of Researchers. The Human Resources Strategy for Researchers (HRS4R) guides research centers of excellence in implementing and upholding these standards within their policies, emphasizing training, professional development, and mobility opportunities.
The IJC’s commitment to these values and principles strengthens our internal policies and ensures that our members have the optimal conditions and environment for their professional development.
The Board of Trustees is composed of representatives of the Generalitat de Catalunya (regional government), University of Barcelona, Autonomous University of Barcelona, the City of Badalona and the Jose Carreras International Leukaemia Foundation
The Catalan government provides hard money on an annual basis. The Jose Carreras International Leukaemia Foundation provides start-up funds, project funds as well as financial support for investments.
The JCI has an international scientific advisory board served by prominent researchers from US and Europe.
The IJC has been awarded ERC and other EU grants.

The IJC is an equal-opportunity employer. We evaluate qualified applicants without regard to race, color, religion, sex, national origin, disability, or other legally protected characteristics.

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